After 5 months, mice lacking p43 had an increased metabolism.

<p>(A) Food intake in 2, 5 and 18 month-old male mice (g/24 h/100 g body weight) (n = 8 in each group). (B) Oxygen consumption (ml/kg/h) measured at 22°C using a Comprehensive Lab Animal Monitoring System (Columbus Instruments, Columbus, OH) in 2, 5 and 18 month-old male mice. Male mice were acclimatized individually in metabolic cages with ad libitum access to standard chow and water for 24-h prior to a 24-h period of automated recordings. Sample air from individual cages was passed through sensors to determine O2 and CO2 content. Statistical Significance: *p<0.05; **p<0.01; ***p<0.001, Student’s <i>t</i>-test. Results are expressed as ±s.e.m.