Altered food intake and RQ in XX versus XY mice.

<p>Mice were individually housed in metabolic cages to assess food take and energy balance parameters continually throughout the diurnal cycle. (A, B) Food intake determined at 4 weeks or 10 months following GDX. Values represent the mean ± SEM food intake summed over two dark or two light periods. Data shown represent raw values; normalization to body weight or to lean body mass gave the same outcome. (C) Food intake patterns throughout 3 nights and 2 days. At left, lines represent mean values for XX (n = 8) and XY (n = 10) mice; at right, lines represent mean values for gonadal females (n = 9) and gonadal males (n = 9). (D, E) Mean Respiratory Quotient (RQ) ± SEM for light and dark periods determined at 4 weeks or 10 months following GDX. At right, the change in RQ between dark and light periods (Δ RQ) is shown. *, p<0.05; **, p<0.01; ***, p<0.001; ‡, p<0.000001.