Knockdown of galectin-3 increases the intracellular epirubicin retention.

<p>Cells were pretreated with scrambled shRNA, shGal-3, and/or Epi for 3 h. (<b>A</b>) Three-dimensional view of cell number versus fluorescence intensity in Caco-2 cells. (<b>B</b>) The mean fluorescence intensity of Epi was normalized to 100%. The mean fluorescence intensity of Epi plus shGal-3 was normalized relative to Epi. *, <i>P</i> < 0.05 compared with control and #, <i>P</i> < 0.05 compared with Epi. The data are presented as the means ± SD from three independent experiments.