Knockdown of galectin-3 changes the mRNA expression levels of Bax, Bcl-2, and caspases after epirubicin treatment.

<p>(<b>A</b>) The effect of treatment with CTR, scrambled shRNA, shGal-3, overGal-3, and/or Epi (1 µg/ml) for 48 h on the mRNA expression level of the apoptosis-related genes encoding Bcl-2 and Bax as determined by real-time PCR. (<b>B</b>) The effect of different treatments on the ratio between the Bax:Bcl-2 mRNA expression. *, <i>P</i> < 0.05 compared with CTR; ⁺, <i>P</i> < 0.05 compared with shGal-3; ^&, <i>P</i> < 0.05 compared with Epi; #, P<0.05 compared with overGal-3.