Knockdown of galectin-3 changes the protein expression of the Wnt/β-catenin signaling and apoptosis-associated pathways after epirubicin treatment.

<p>GSK-3β and Bax were upregulated after the treatment of galectin-3 knockdown cells. The expression of the anti-apoptotic protein Bcl-2 was significantly reduced in galectin-3 knockdown cells. The simultaneous downregulation of pGSK-3β, β-catenin, c Myc, and the pro-apoptotic protein Bcl-2 was also found.