Cobalt and nickel prolong the half-life of OCT4.

<p>A. Tera-1 cells were treated with cycloheximide (CHX) in the presence of absence of NiCl₂ for various times. Equal amounts of cell lysates were blotted with indicated antibodies. B. OCT4 signals shown in <i>A</i> were quantified and plotted. T_1/2 denotes an estimated half-life. C. Tera-1 cells were treated with CHX in the presence of absence of CoCl₂ for various times. Equal amounts of cell lysates were blotted with indicated antibodies. D. OCT4 signals shown in <i>C</i> were quantified and plotted. T_1/2 denotes an estimated half-life.