Decreased functional synapses in cultured afadin-deficient hippocampal neurons.

<p>(A) Example mEPSC traces. The vertical and horizontal bars denote 5 pA and 1 s, respectively. (B) The average interevent interval of mEPSCs (n = 12 in both the control and <i>afadin</i> cKO neurons). (C) Appearance of the cultured neurons used for analysis of mEPSCs. The neuron density is similar between control and <i>afadin</i> cKO neurons. Scale bars, 200 µm. Control, <i>afadin</i>^+/f; cKO, <i>afadin</i>^f/f;nestin-Cre.