The anti-diabetic effects of ZBPYR on db/db mice.

<p>(<b>A</b>) RBG was examined weekly during ZBPYR administration. ZBPYR significantly reduced glucose levels from the 3rd week to the 6th week. (<b>B</b>) FSI was accessed at the end of the administration period and after the animals had been starved for 12 h. (<b>C–D</b>) OGTT (2 g/kg body weight) was performed at the end of the administration period and after the animals had been starved for 14 h. Actual glucose levels were measured at the indicated times (<b>C</b>), and then the AUC was analyzed (<b>D</b>). (<b>E–F</b>) ITT (0.75 U/kg body weight) was performed at the end of the administration period and after the animals had been starved for 6 h. Actual glucose levels were measured at the indicated times (<b>E</b>), and then the AUC was analyzed (<b>F</b>). Values are means ± S.D. from 17 mice in each group. *<i>p</i><0.05 compared to control; ^#<i>p</i><0.05 compared to DM.