<i>In vivo</i> effects of hAd on glycaemic control in diabetic db/db mice.

<p>The animals were dosed intraperitoneally once daily with metformin (closed triangles) or twice daily with hAd (open squares) or vehicle (open circles) for 14 days. Blood glucose profiles were taken at day 0 (<b>A</b>), day 6 (<b>B</b>) and day 13 (<b>C</b>) of the study at 7 a.m., 10 a.m., 1 p.m., 3 p.m., 6 p.m., and 9 p.m. HbA_1c (<b>D</b>) was measured on the same days and additionally 7 and 14 days before the start of dosing. Body weight (<b>E</b>) was monitored daily. The data is representative for all studies performed with db/db mice. The data for all other forms of adiponectin is summarized in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044270#pone-0044270-t002" target="_blank">Table 2</a>.