Postmortem analyses of IDUA-KO mice treated with MSC-KO-IDUA by histology and cytokine production.

<p>Kidneys from three treated mice were stained with Hematoxylin-Eosin (A). Inflammatory infiltrate in the cortex (*), replacement of normal tissue by inflammatory infiltrate in the renal medulla (→), thickening of the Bowman's capsule (???) and reduction of the lumen of the renal tubules (▹) were marked in the figure. Cytokine production was then evaluated using blood samples from the three treated and two non-treated mice 15 days after the last cell transplantation (B). Only TNF-alpha was detected in the treated mice. *p<0.0001 by the paired student t-test.