Anaplerotic triheptanoin diet normalizes steady-state betahydroxybutyrate (BHBA) in liver and muscle of <i>Mecp2</i> KO mice.

<p><i>Mecp2</i> KO mice fed either chow or high-soybean oil control diet (SBO) had elevated levels of BHBA versus WT controls in both (A) liver and (B) skeletal muscle. <i>Mecp2</i> KO mice fed triheptanoin diet (Trihep) did not show elevated levels of this ketone body. Data in bar graphs were normalized to the median of the WT+chow control group, median scaled to 1, but are presented as averages with standard errors. Symbols denote group differences by ANOVA contrast comparisons of log-transformed data (p≤0.05): asterisk, differs from matching chow control, dagger, differs from matching WT control; double dagger, differs from matching SBO control.