Triheptanoin diet improves glucose sensitivity in <i>Mecp2</i> KO mice.

<p>(A–C): Blood glucose levels after intraperitoneal glucose injection (1 mg/kg) at 4 weeks (A), 6 weeks (B), and 8 weeks of age (C) in chow-fed WT or <i>Mecp2</i> KO mice (WT vs. KO *p<0.05, **p<0.01, ***p<0.001; two-way ANOVA with Bonferroni <i>post hoc</i> test; 4wk CHOW WT n = 6, 4 wk CHOW KO n = 8). (D, E): Blood glucose levels after intraperitoneal glucose injection (1 mg/kg) at 6 weeks (D) and 8 weeks (E) of age after two (D) or four (E) weeks of SBO or triheptanoin diet in WT or <i>Mecp2</i> KO mice (SBO-KO vs. other groups *p<0.05, **p<0.01, ***p<0.001; two-way ANOVA with Bonferroni <i>post hoc</i> test; n = 4 per group). Inserts represent areas under the curves (AUC). For AUC inserts of panel D and E, dagger symbols denote differences from matching WT control, double daggers denote differences form matching SBO control. All graphs represent data as mean±s.e.m.