Triheptanoin lowers leptin and insulin levels in <i>Mecp2</i> KO mice.

<p>(A) Serum levels of leptin, insulin, and adiponectin measured by Multiplex assay at 8 weeks of age in <i>Mecp2</i> KO mice and WT littermates (SBO WT n = 14, C7TG WT n = 12, SBO KO n = 15, C7TG n = 14). (B) Weight of WAT in SBO- or triheptanoin-fed WT and KO mice (SBO WT n = 6, C7TG WT n = 4, SBO KO n = 6, C7TG KO n = 5). (C) Expression levels of <i>leptin</i> mRNA from WAT, data for each group are fold-changes relative to SBO WT control with actin as a reference gene (SBO WT n = 9, C7TG WT n = 11, SBO KO n = 10, C7TG KO n = 8). For all panels A-C, two-way ANOVA with Tukey <i>post hoc</i> test; dagger symbol, differs from matching WT control; double dagger, differs from matching SBO control; p<0.05. All graphs represent data as mean±s.e.m.