1MT treatment reduces IL-12 and increases IL-6 and TGF-β production by A/J and B10.A macrophages.

<p>(<b>A, B</b>) IFN-γ-primed and unprimed macrophages were treated with 1MT or left untreated and then cultivated for 48 h. Some cultures were infected with viable <i>P. brasiliensis</i> yeasts (1∶25, fungus∶macrophages ratio) for 48 h. Supernatants were removed and used for cytokine measurements by means of ELISA. Data are means ± SEM of triplicate samples from three independent determinations (*<i>p</i><0.05, **<i>p</i><0.01 and ***<i>p</i><0.001).