Cytokine levels in BAL after <i>P. brasiliensis</i> infection. WT and 5-LO^−/− mice were infected with 10⁶<i>P. brasiliensis</i> yeasts.

<p>Cytokine levels for TNF-α (A), IFN-γ (B), IL-1β (C), IL-6 (D), CXCL-1/KC (E) and CXCL-2/MIP-2 (F) was determined by ELISA in BAL after 24 and 72 h of infection. The data were expressed as mean ± SEM (n = 5). Symbol * represents significant difference (*p<0.05, **p<0.01, ***p<0.001) between infected mice compared to respective control group. Symbol ^† represents significant difference (^†p<0.05, ^††p<0.01, ^†††p<0.001) to infected mice counterparts in evaluated periods. Symbol ^‡ represents significant difference (^‡p<0.05, ^‡‡‡p<0.001) between WT and 5-LO^−/− mice in the respective periods evaluated. ND, not detected.