NO^. fails to modify the alloantigen T-cell response but enhances the release of IL-17 during a MLR.

<p>DCs were simulated in time-dependent experiments with DPTA NONOATE^. 0.6mM and LPS 100ng/ml. 1×10⁵ responder T-cells used for allogenic MLR assays were added to washed DCs for 6 days. A-E, Bioplex of IL-17, IFN-γ, TNF-α, IL-6, IL-13 in 6-day culture at a DC:T-cell ratio of 1:10. Data are expressed as means ±SEM of 7 independent experiments for IL-17 and 6 independent experiments for IFN-γ, TNF-α, IL-6, IL-13. F, T-cell proliferation was measured by incorporation of thymidine at DC:T-cell ratios of 1:10, 1:50 and 1:100. Data are expressed as means ±SEM from 3 independent experiments done in triplicate. *P < 0.05.