ROI analysis: Group effect in the Emotion Model.

<p><i>Upper panel</i>: Activation in the amygdalae in response to emotional faces showing a group effect (CD patents > healthy controls). Statistical maps have been thresholded at p<0.005 uncorrected for display purposes. A significant increased activity was found in the left amygdala (FWEp = 0.027, z = 3.3, [–22–8–14]). Of note, the right amygdala activation displayed here did not reach conventional levels of significance after correction for multiple comparisons (FWE p = 0.078 at MNI [22–4–14]). <i>Lower panel</i>: Graph showing contrast estimates for left amygdala activation in response to each negative emotion (sad, fear) separately for the 2 groups: CD patients (in orange) and healthy controls (in green).