<i>lrp5</i> morphants display normal induction but defective migration of CNCCs.

<p>(<b>A-D</b>) Embryos at 10 ss stained for <i>foxd3</i> transcripts. (A,B) Wild-type embryo, (C,D) <i>lrp5</i> morphant. Note normal pattern of <i>foxd3</i> expression in morphants. (<b>E-N</b>) Embryos at 20 ss stained for <i>dlx2a</i>. (E-I) Wild-type embryo, (J-N) <i>lrp5</i> morphant. Note ectopic <i>dlx2a</i> expression at dorsal neuroepithelium of rhombomere 6 in <i>lrp5</i> morphants (asterisk in J,N; arrow in L) and that streams of branchial migratory CNCCs are reduced (M). (<b>O-X</b>) <i>crestin</i> expression in embryos at 20 ss. (O-S) Wild-type embryo, (T-X) <i>lrp5</i> morphant. Note ectopic <i>crestin</i> expression at dorsal neuroepithelium of rhombomere 6 in <i>lrp5</i> morphants (asterisk in T,X; arrow in V) and that streams of branchial migratory CNCCs are reduced (M). (<b>Y,Z</b>) Confocal projections of <i>sox10</i>:GFP embryos at 20 ss showing GFP expression in CNCCs. (Y) Uninjected control embryo, (Z) <i>lrp5</i> morphant. Note ectopic GFP cells at dorsal neuroepithelium of rhombomere 6 in <i>lrp5</i> morphants (arrow) and that streams of branchial migratory CNCCs are reduced. Anterior is to the left in all images, except cross sections. Boxed areas indicate regions shown in higher magnification in accompanying images. Positions of cross sections in I,N,S,X are indicated by lines in F,K,P,U.