<p>OGTT time course and AUC in normal mice (A, B), HFD/STZ mice (C, D) and <i>db/db</i> mice (E, F). Values represent mean ± SD (n = 10). *p<0.05, **p<0.01, ***p<0.001 vs. vehicle group. Asterisks in A, C and E reflect significance between WB403 100 mg/kg and vehicle group.</p
<p>A) Body weight B) serum insulin levels, and C) blood glucose during i.p. glucose tolerance test (...
<p>(A) Body weight in grams of nine-week old WT and <i>db/db</i> mice. (B) Blood glucose levels in t...
<p>Blood glucose levels in OGTT before (<b>A</b>) and after HFD feeding (<b>D</b>). Blood glucose le...
<p>Mice were treated with different concentration of WB403, vehicle or sitagliptin. FBG (A) and PBG ...
<p>(A, B) FBG and PBG measured every week during the 4-week treatment period. (C, D) Serum levels of...
<p>A) Fasted glucose of WT (n = 6) and T1R3 KO (n = 9) mice. B) IP GTT in WT (n = 6) and T1R3 KO (n ...
<p>The indicated doses of novel compounds (codes and chemical structures shown above the bar graphs)...
<p>A and C showed results of OGTT in each group at the fifth and the tenth week. B and D showed area...
<p>(A, D) No significant change was observed on blood glucose levels during the OGTT between vehicle...
<p>Effect of feeding 180 mg/kg 55P0110 to 9 weeks-old (<b>A</b>) or 90 mg/kg 55P0110 to 12 weeks-old...
<p>(A) Blood glucose levels in vehicle- and empagliflozin-treated (3mg/kg for 8 days) mice during an...
<p>Intraperitoneal (Panel <b>A</b>) and oral (Panel <b>B</b>) glucose tolerance tests were performed...
<p>(A) Intraperitoneal glucose tolerance test (ipGTT) in males after 16 wk of HFD. (B) Respective ar...
(A) Glucose tolerance test (n = 6–9 mice/group). (B) Insulin tolerance test (n = 6–16 mice/group). (...
<p>WT (n = 5) and KO (n = 7) mice were fasted for 16 h, and then injected i.p. with D-glucose (2 mg/...
<p>A) Body weight B) serum insulin levels, and C) blood glucose during i.p. glucose tolerance test (...
<p>(A) Body weight in grams of nine-week old WT and <i>db/db</i> mice. (B) Blood glucose levels in t...
<p>Blood glucose levels in OGTT before (<b>A</b>) and after HFD feeding (<b>D</b>). Blood glucose le...
<p>Mice were treated with different concentration of WB403, vehicle or sitagliptin. FBG (A) and PBG ...
<p>(A, B) FBG and PBG measured every week during the 4-week treatment period. (C, D) Serum levels of...
<p>A) Fasted glucose of WT (n = 6) and T1R3 KO (n = 9) mice. B) IP GTT in WT (n = 6) and T1R3 KO (n ...
<p>The indicated doses of novel compounds (codes and chemical structures shown above the bar graphs)...
<p>A and C showed results of OGTT in each group at the fifth and the tenth week. B and D showed area...
<p>(A, D) No significant change was observed on blood glucose levels during the OGTT between vehicle...
<p>Effect of feeding 180 mg/kg 55P0110 to 9 weeks-old (<b>A</b>) or 90 mg/kg 55P0110 to 12 weeks-old...
<p>(A) Blood glucose levels in vehicle- and empagliflozin-treated (3mg/kg for 8 days) mice during an...
<p>Intraperitoneal (Panel <b>A</b>) and oral (Panel <b>B</b>) glucose tolerance tests were performed...
<p>(A) Intraperitoneal glucose tolerance test (ipGTT) in males after 16 wk of HFD. (B) Respective ar...
(A) Glucose tolerance test (n = 6–9 mice/group). (B) Insulin tolerance test (n = 6–16 mice/group). (...
<p>WT (n = 5) and KO (n = 7) mice were fasted for 16 h, and then injected i.p. with D-glucose (2 mg/...
<p>A) Body weight B) serum insulin levels, and C) blood glucose during i.p. glucose tolerance test (...
<p>(A) Body weight in grams of nine-week old WT and <i>db/db</i> mice. (B) Blood glucose levels in t...
<p>Blood glucose levels in OGTT before (<b>A</b>) and after HFD feeding (<b>D</b>). Blood glucose le...