FBG1 knockout increases A1AT-Z accumulation in the mouse liver.

<p>Livers were harvested from 6-month-old FBG1 ^+/0 A1AT-Z ^tg/0 and FBG1 ^+/+ A1AT-Z ^tg/0 mice. Total cell lysates were separated on SDS-PAGE gels and probed with the following antibodies against A1AT and stained for total protein (loading control) (n = 3). Densitometry of A1AT normalized to loading control indicated a 1.8-fold increase in A1AT in FBG1 knockout liver (FBG1 ^+/0 A1AT-Z ^tg/0) compared to wild-type FBG1 liver (FBG1 ^+/+ A1AT-Z ^tg/0).