Liver-specific deletion of PGC-1β.

<p>[<b>A</b>] The graph shows the expression of PGC-1β (Ppargc1b) mRNA in liver of 6 week old female WT (fl/fl) or littermate LS-PGC-1β^−/− mice (n = 5). *P<0.05 versus WT mice. Inset is a western blot using liver lysates from the same mice. Lysates from cells infected with an adenovirus to overexpress PGC-1β were used as a positive control. [<b>B</b>] The graphs show hepatic triglyceride and cholesterol content in liver of 6 week old WT (fl/fl) or littermate LS-PGC-1β^−/− mice (n = 5). [<b>C</b>] The graphs represent mean plasma glucose, triglyceride (TG), and cholesterol concentrations in WT and LS-PGC-1β^−/− littermate mice. [<b>D</b>] The graph depicts rates of TG secretion in WT and LS-PGC-1β^−/− littermate mice after injection with Triton WR-1339 to inhibit VLDL lipolysis. [<b>E</b>] Representative H&E stained sections of liver from 6 week old WT and LS-PGC-1β^−/− littermate mice are shown. [<b>F</b>] The graphs represent mean plasma ALT and AST concentrations in WT and LS-PGC-1β^−/− littermate mice.