Apamin boosts EPSPs in Ca_V2.3^-/- mice.

<p>(A) Time course of the normalized EPSP amplitude (mean ± s.e.m.) for baseline in control aCSF (Ctrl) and during wash-in of apamin (100 nM) as indicated above (n = 18) in Ca_V2.3^-/- (blue symbols) and WT (black symbols) mice. (B) Average of 15 EPSPs taken from indicated shaded time points in aCSF (black) and 16–20 min after application of apamin (red); shaded areas are mean ± s.e.m. (C) Scatter plot of relative ESPS peak compared to baseline (Ctrl) from the individual slices in panel A for Ca_V2.3^-/- (blue symbols) and WT (black symbols). Horizontal bar reflects mean response.