PF-EPSCs in wild-type and APP/PS1 PCs.

<p>(<b>A</b>) Representative traces of PF-EPSCs evoked by paired-pulse stimulation with an interpulse interval of 100 ms in wild-type (blue) and APP/PS1 (red) mice. Five traces obtained with stimulus strength from 3 to 15 µA are superimposed. (<b>B</b>) Amplitudes of PF-EPSCs are plotted as a function of stimulus intensity for wild-type (blue circles, n = 14) and APP/PS1 (red squares, n = 17) PCs. (<b>C</b>) Time course of paired-pulse facilitation of PF-EPSC in wild-type (blue circles, n = 17) and APP/PSl mice (red squares, n = 14). The facilitation is expressed as the percentage of the second EPSC relative to the first one (mean ± SEM) and is plotted as a function of interstimulus interval.