Paired-pulse ratio recorded from EGFP-labeled, GABAergic neurons following dorsal root stimulation is increased after CCI treatment.

<p>(<b>A</b>) Overlaid monosynaptically evoked Aδ-fiber EPSCs during 10 Hz stimulation (scale bars: 10 ms, 50 pA). (<b>B</b>) Averaged traces of paired-pulse recordings following Aδ-fiber stimulation at 50 ms interstimulus interval (scale bars: 20 ms, 100 pA). (<b>C</b>) Paired-pulse ratio following Aδ-fiber stimulation was increased in CCI treated mice at 50 ms interstimulus interval (sham n = 19, CCI n = 20, ** P < 0.01, two-way ANOVA) and at 300 ms interstimulus interval (sham n = 21, CCI n = 20, * P < 0.05, two-way ANOVA). Data: mean ± s.e.m. (<b>D</b>) Overlaid monosynaptically evoked C-fiber EPSCs during 1 Hz stimulation (scale bars: 10 ms, 50 pA). (<b>E</b>) Averaged traces of paired-pulse recordings following C-fiber stimulation at 300 ms interstimulus interval (scale bars: 100 ms, 100 pA). (<b>F</b>) Paired-pulse ratio following C-fiber stimulation was increased in CCI treated mice at 300 ms interstimulus interval (sham n = 13, CCI n = 13, ** P < 0.01, two-way ANOVA) and at 500 ms interstimulus interval (sham n = 16, CCI n = 16, * P < 0.05, two-way ANOVA). Data: mean ± s.e.m.