Effects of apamin on <i>I</i>_K1 and <i>I</i>_to in transfected HEK 293 cells.

<p>(A) The representative tracings of <i>I</i>_K1 by ascending voltage ramp protocol shown in the inset before apamin (a), after apamin (b) and after CsCl (c) at time points indicated by arrows a through c, respectively, in (B). (B) The time course of <i>I</i>_K1 at –100 mV. (C) The summary of drug effects normalized to baseline. (D) The representative tracings of <i>I</i>_to obtained by a pulse protocol shown in the inset before apamin (a), after apamin (b) and after 4-AP (c) at time points indicated by arrows a through c, respectively, in (E). (E) The time course of peak <i>I</i>_to at 20 mV. (F) The summary of drug effects normalized to baseline.