Effects of AP-5 application on EPSCs in control and hyperglycemic mice.

<p><b>A.</b> Representative trace showing sEPSCs in a DMV neuron from a control mouse in control ACSF and during application of AP-5 (100 μM). <b>B.</b> Representative trace showing sEPSCs in a DMV neuron from a hyperglycemic mouse (STZ) before and during application of AP-5. Arrows point to expanded sections of traces indicated in <b>A</b> and <b>B</b>. <b>C.</b> Mean percent decrease in sEPSC frequency following application of AP-5 in control (n = 5) and hyperglycemic (n = 6) mice (asterisk indicates significant difference from control mice; p<0.05, Mann-Whitney U test). <b>D.</b> Mean percent decrease in mEPSC frequency following application of AP-5 in control (n = 9) and hyperglycemic (n = 10) mice. No difference was detected in the effect of AP-5 on mEPSC frequency in neurons from hyperglycemic and control mice (p = 0.97, Mann-Whitney U test).