Boosting of EPSPs by SNX in the presence of apamin requires Ca_V2.3 R-type Ca²⁺ channels.

<p>(A) Time course of the normalized EPSP amplitude (mean ± s.e.m.) for baseline in apamin (100 nM) and during wash-in of SNX (300 nM) in the presence of apamin (n = 19). Inset shows the average of 15 EPSPs taken from indicated shaded time points in apamin and 15–20 min after co-application of SNX; shaded areas are mean ± s.e.m. (B) Plot of relative EPSPs after SNX application in the presence of apamin versus the basline EPSP in apamin alone from all cells (n = 19).