Ocular IgG and IgA responses following heterologous prime-boost intramuscular vaccination.

<p>BALB/c mice were immunised using different heterologous prime-boost vaccine regimes (A). Samples from the surface of the eye were collected two weeks after the final immunisation and assessed by ELISA for MOMP-specific ocular IgG (B). Specific IgG was normalised to the level of total ocular IgG in the same sample (C). MOMP specific IgA was in ocular fluid was assessed by ELISA (D). Points represent individual mice, lines represent mean (n = 8 per group), +/- SEM. ** p ≤ 0.005, and **** p ≤ 0.0001 by one-way ANOVA with Tukey’s multiple comparison post-test.