Single-cell extrusion with subsequent regeneration in the kidney of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice.

<p>(<b>A</b>) A representative photograph of a single tubular cell extrusion (<i>triangles</i>) from the epithelial layer of proximal tubules at day 3. Scale bar = 10 μm. (<b>B</b>) Counts of mitotic cells per field on proximal tubules of control (<i>white bar</i>) and DDC-fed mice (<i>black bar</i>) at days 1, 3, and 7. (<b>C</b>) Counts of Ki-67-positive cells per field on proximal tubules of control (<i>white bar</i>) and DDC-fed mice (<i>black bar</i>) at days 1, 3, and 7. Data are presented as means ± SEM. *<i>P</i> < 0.05 compared with control mice. (<b>D</b>) Immunohistochemical staining for Ki-67 in the proximal tubules of control and DDC-fed mice at days 1, 3, and 7. Scale bar = 100 μm.