Numbers of Ki67-positive proliferative tubular epithelial and interstitial cells in UUO kidneys.

<p>(<b>A–E</b>) Sections of CLK kidneys in WT mice (<b>A</b>) and UUO kidneys in WT (<b>B</b>), Skp2^−/− (<b>C</b>), Skp2^−/−p27^−/− (<b>D</b>) and p27^−/− (<b>E</b>) mice were subjected to immunostaining with an anti-Ki67 antibody, scale bars: 50 µm (<b>F, G</b>) The numbers of Ki67-positive tubular epithelial cells (<b>F</b>) and Ki67-positive interstitial cells (<b>G</b>) in the UUO kidneys were counted in the mice of each genotype. The CLK kidneys in WT mice were evaluated as controls. *<i>P</i><0.05, **<i>P</i><0.01 versus WT CLK kidneys, ^#<i>P</i><0.05 versus WT UUO kidneys and ^†<i>P</i><0.05, ^††<i>P</i><0.01 versus Skp2^−/− UUO kidneys.