Effect of mTPOR-MBP on the development of lung damage in the LPS model.

<p>(A) Representative micrographs of lung histology in LPS-injected mice untreated (upper panel) or treated (lower panel) with mTPOR-MBP at the indicated time-points (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for experimental details). Original magnification, X200. Black bars, 50 μm. (B) Quantification of neutrophil infiltration within lung septa after LPS administration, in mice treated (dashed columns) or not (black columns) with mTPOR-MBP (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for methodological details). (C) Quantification of lung septal thickening after LPS administration, in mice treated (dashed columns) or not (black columns) with mTPOR-MBP (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for methodological details). The number of animals studied per experimental group was as follows: Control (C) = 6; mTPOR-MBP alone = 5; LPS 3h = 7; LPS 3h + mTPOR-MBP = 10; LPS 6h = 6; LPS 6h + mTPOR-MBP = 5. * <i>P</i> < 0.05; ** <i>P</i> < 0.01.