Effects of Gu-4 on lung injury and LA level of lung tissue in septic mice.

<p>A: Lung tissues from saline-treated mice exhibited normal architectures. B: Lung tissues from LPS-challenged mice showed severe edema and leukocyte infiltration as indicated with black arrows. C: Lung tissues from Gu-4-treated LPS-challenged mice showed normal architectures and significant decrease of inflammatory cell infiltration. D: Semi-quantitative scoring of lung injury was determined as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030110#s4" target="_blank">Materials and Methods</a>. The lung injury was seriously induced by LPS but was attenuated by Gu-4. E: LA level in lung tissue from septic mice is significantly higher than those from normal mice and Gu-4-treated LPS- challenged mice. Magnification: ×200. *: p<0.05 <i>vs</i>. Normal; #: p<0.05 <i>vs</i>. LPS + Saline.