Effect of mTPOR-MBP on the development of liver and intestinal damage in the LPS model.

<p>(A) Representative micrographs of liver histology in LPS-injected mice untreated (upper panel) or treated (lower panel) with mTPOR-MBP at the indicated time-points (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for experimental details). Original magnification, X200. Black bars, 50 μm. (B) Quantification of hepatic micro-abscesses after LPS administration, in mice treated (dashed columns) or not (black columns) with mTPOR-MBP (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for methodological details). (C) Representative micrographs of gut histology in LPS-injected mice untreated (upper panel) or treated (lower panel) with mTPOR-MBP at the indicated time-points (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for experimental details). Original magnification, X200. Black bars, 50 μm. (D) Quantification of intestinal villus diameter after LPS administration, in mice treated (dashed columns) or not (black columns) with mTPOR-MBP(see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0151088#sec006" target="_blank">Materials and Methods</a> for methodological details). The number of animals studied per experimental group was as follows: Control (C) = 6; mTPOR-MBP alone = 5; LPS 3h = 7; LPS 3h + mTPOR-MBP = 10; LPS 6h = 6; LPS 6h + mTPOR-MBP = 5. * <i>P</i> < 0.05; ** <i>P</i> < 0.01; *** <i>P</i> < 0.001.