Markers of oxidative stress are altered with changes in mtFASII functionality.

<p>Levels of metabolites from the γ-glutamyl cycle were analyzed in whole ACP KD and MECR OX cells and their respective controls using metabolomics, which included UHLC/MS/MS and GC/MS, as described in Experimental Procedures. Gamma-glutamyl cycle intermediates that were identified are indicated with arrows and a corresponding box plot. Y-axes for box plots indicate scaled intensity. Direction of metabolite level change compared to control in ACP KD cells is indicated by gray arrows, and direction of metabolite level change relative to control in MECR OX is indicated by blue arrows. In box plots, metabolite levels are shown for ACP KD cells, MECR OX cells, and their respective controls. For each box, n = 6 and open circles indicate extreme data points.