Metabolites of the TCA cycle and glutaminolysis.

<p>Schematic illustration of relevant reactions from the TCA cycle and glutaminolysis. Absolute intracellular amounts of monitored metabolites are presented as bar charts (nmol per 10⁶cells). Changes in the extracellular concentrations are shown as line graphs expressing the differences between the concentrations of the sample at the respective time points and the initial concentration in the medium. Data are presented as means ± SD without (light grey) and with rHla treatment (dark grey) at 30, 60 and 120 min (n = 3). Asterisks indicate significant p-values (α = 0.05 after Holm-Šidák correction) between the treated cells and the corresponding control. Triangles indicate significant p-values between the two cell lines during control conditions (grey) or during rHla-treatment (black).