Lipid homeostasis is altered by ACP KD and MECR OX.

<p>Levels of metabolites from lipid synthesis and degradation pathways were analyzed in whole ACP KD and MECR OX cells and their respective controls using metabolomics, which included UHLC/MS/MS and GC/MS, as described in Experimental Procedures. Lipid synthesis and degradation intermediates that were identified are indicated with arrows and a corresponding box plot. Y-axes for box plots indicate scaled intensity. Direction of metabolite level change compared to control in ACP KD cells is indicated by gray arrows, and direction of metabolite level change relative to control in MECR OX cells is indicated by blue arrows. In box plots, metabolite levels are shown for ACP KD cells, MECR OX cells, and their respective controls. For each box, n = 6 and open circles indicate extreme data points.