Blockade of CB1 Receptors Produces Broadband Changes in EEG Power Spectral Features.

<p>Results are from experiment where AM281 was administered at the onset of the LP. <b>A—C</b>, Average of power spectra for each photoperiod and for each vigilance state across different days of the experiment. Solid lines indicate mean of all subjects as a function of frequency, and shaded regions surrounding lines denotes standard error of the mean. <b>A,</b> Power spectra from wake epochs. <b>B</b>, Power spectra from NREM epochs. <b>C</b>, Power spectra from REM epochs. <b>D–F</b>, Average power in specified bandwidths in each state for 3 Hr epochs over the day. Data from each vigilance state are color coded with wake in red (<b>D</b>), NREM in blue (<b>E</b>), and REM in green (<b>F</b>). Gray backgrounds indicate the DP. Asterisks (*) denote significant pair-wise comparisons between drug conditions and measures obtained during vehicle baseline. Symbols represent means±SEM across all subjects (<i>N</i> = 9) for each 3 Hr time bin.