Power changes in the alpha and beta bands by celecoxib treatment.

(A) The topography of EEG spectral power differences in alpha (upper) and beta (lower) frequency bands at baseline (a), after a single dose of placebo or celecoxib (400 mg) (b), and after a 7-day treatment regimen (c). (B) Celecoxib (400 mg once) treatment increased the power of the frontal lobe (a), parietal lobe (b), and total brain (c) areas at the alpha band and beta frequency in the central (d) and parietal (e) regions. However, this effect was not evident after 7 days of treatment (200 mg twice a day). Asterisks denote statistical significance (Wilcoxon signed rank test, p < 0.05). Abbreviations: 4 h, 4 hours; 7 d, 7 days.