Effects of pharmacological blockade of GJ channels on epileptiform potentials during status epilepticus (SE).

<p>(A, B, C) Representative spectrograms of the raw ECoGs from Control CBX, SE and SE+CBX groups, showing the main frequencies, evidenced by the color intensity, which compose the signal during the 2-hour interval after injection of CBX or saline. Note the increase of ECoG power in the SE group (B) and the reduction of color intensity after CBX treatment (C), showing the decrease of power of all frequency bands, especially the beta frequency. Representative power spectra of SE+CBX group. (D, E) Power spectrum of basal and methyl-scopolamine periods shows similar frequency composition. (F) It is possible to observe that pilocarpine-induced SE enhanced the power of all frequency bands, especially at 12–35 Hz range. (G–K) CBX administration 30 minutes after SE establishment caused notable decrease of the power in the beta frequency oscillations observed in the following 2 hours. Since we found that the reduction of beta oscillations occurs during the evolution of SE (data not shown), we tested whether this reduction was significant when compared to the same periods of SE group. (L) We observed that the time period for reduction in the beta frequency range was significantly decreased in the animals that received CBX injection. Bars represent standard errors of mean. *<i>P</i><0.01 in T-Test.