Electrophysiological effects of drugs acting on endocannabinoid system in avoiding (AV) and approaching (AP) mice.

<p>(<b>A</b>) The graph shows that treatment with URB597 was able to rescue the effect of the CB1 receptor agonist HU210 on sIPSC frequency in neurons from the AV animals. The HU210-induced inhibition of sIPSC frequency in AV+URB animals was comparable to that seen in BA animals. The treatment with the CB1 receptor antagonist AM251 fully abolished HU210 responses in AP mice. (<b>B</b>) The counterbalanced pharmacological manipulations between categories showed that in AV mice blockade of CB1 receptors with AM251 did not modify HU210 responses of GABAergic striatal neurons, while the treatment of AP animals with URB maintained the high sensitivity of striatal GABAergic synapses to HU210. Asterisks indicate the significance level of the comparisons between AV+URB <i>vs.</i> AV+VHL animals and AP+AM <i>vs.</i> AP+VHL animals: * <i>P</i><0.05.