FIN-induced MDSCs suppress T cells proliferation.

<p><b>(A)</b> Functional analysis of FIN-induced MDSCs from healthy PBMCs. FIN-induced MDSCs were sorted by flow cytometry. Autologous T cells were stimulated with anti-CD3/28 and co-cultured with MDSCs at different ratios for 3 days. T-cell proliferation was measured by CFSE dilution. Unstimulated T cells were used as negative control (NC). Results are representative of three healthy individuals. <b>(B)</b> The percentage of proliferation for CD4⁺ T cells and CD8⁺ T cells. Mean ± SEM from three independent experiments is shown. *p<0.05, **p<0.01, compared with stimulated T cells cultured alone by student’s t-test.