<p>Factor levels: 2 sets of 50 studies, CGR equal to 1 within both sets, 100k independent SNPs, and arising from a subset of 1k independent SNPs.</p
<p>Note:</p><p>The causal relationship of the SNPs was examined by comparing adjusted/conditional mo...
<p>The proportion of simulated traits for which the -log10(p) value of the causal SNP is above the t...
<p>N-FHS = Number of records from Framingham, N-GEN = Number of records from GENEVA. G-BLUP uses 400...
<p>Factor levels: 50 studies, sample size 5,000 individuals per study, 100k independent SNPs, and he...
<p>Note: The horizontal axis denotes the positions of the causal SNPs in the corresponding genes (Ai...
<p>The plot shows the powers (y-axis) of each method over the different LD and MAF structures (x-axi...
<p>The plot shows the powers (y-axis) of each method over the different LD and MAF structures (x-axi...
<p>(A) 100% causal SNVs within all genes, estimated with SKAT. (B) 100% causal SNVs within each gene...
<p>The causal SNP on the <i>x</i>-axis has been ordered by the median <i>R</i><sup>2</sup> in ascend...
<p>The theoretic calculation assumes <i>M</i> = 53,163 independent SNP, of which 5,000 are causal fo...
<p>The figure shows the empirical power given the significance level of 0.05. Top row: 50 variants i...
<p>Note: In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062129#pone-00621...
<p><b>Panel A</b> shows the simulated power for the sex-stratified model, <b>Panel B</b> shows the p...
<p>The model is parameterized in terms of the percentage of variance in the biological intermediate ...
<p>Plots illustrate the power of the methods when the total number of associated SNPs equals 100 (pl...
<p>Note:</p><p>The causal relationship of the SNPs was examined by comparing adjusted/conditional mo...
<p>The proportion of simulated traits for which the -log10(p) value of the causal SNP is above the t...
<p>N-FHS = Number of records from Framingham, N-GEN = Number of records from GENEVA. G-BLUP uses 400...
<p>Factor levels: 50 studies, sample size 5,000 individuals per study, 100k independent SNPs, and he...
<p>Note: The horizontal axis denotes the positions of the causal SNPs in the corresponding genes (Ai...
<p>The plot shows the powers (y-axis) of each method over the different LD and MAF structures (x-axi...
<p>The plot shows the powers (y-axis) of each method over the different LD and MAF structures (x-axi...
<p>(A) 100% causal SNVs within all genes, estimated with SKAT. (B) 100% causal SNVs within each gene...
<p>The causal SNP on the <i>x</i>-axis has been ordered by the median <i>R</i><sup>2</sup> in ascend...
<p>The theoretic calculation assumes <i>M</i> = 53,163 independent SNP, of which 5,000 are causal fo...
<p>The figure shows the empirical power given the significance level of 0.05. Top row: 50 variants i...
<p>Note: In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0062129#pone-00621...
<p><b>Panel A</b> shows the simulated power for the sex-stratified model, <b>Panel B</b> shows the p...
<p>The model is parameterized in terms of the percentage of variance in the biological intermediate ...
<p>Plots illustrate the power of the methods when the total number of associated SNPs equals 100 (pl...
<p>Note:</p><p>The causal relationship of the SNPs was examined by comparing adjusted/conditional mo...
<p>The proportion of simulated traits for which the -log10(p) value of the causal SNP is above the t...
<p>N-FHS = Number of records from Framingham, N-GEN = Number of records from GENEVA. G-BLUP uses 400...