<p>N-FHS = Number of records from Framingham, N-GEN = Number of records from GENEVA. G-BLUP uses 400 K SNPs, wG-BLUP uses 400 K SNPs, but the contribution of each SNP to the genomic relationship matrix was weighted using as weight, where is the SNP associated p-value reported by <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003608#pgen.1003608-LangoAllen1" target="_blank">[5]</a>.</p
<p>PPH-1 – PolyPhen-1; PPH-2 – PolyPhen-2; PMD dataset – dataset from Protein Mutant Database; MMP –...
Background Genomic prediction requires estimation of variances of effects of single nucleotide polym...
<p>FHS = Framingham Heart Study, GEN = GENEVA, RAND: in this scenario causal and marker loci were dr...
Motivation: Using simulation studies for quantitative trait loci, we evaluate the prediction quality...
<p>Cross-validation revealed steady gains in prediction accuracy with respect to the NAM family-stra...
<p>Odds ratios (black squares) from the complete multivariate model (“chromstate+eqtl [M3]”) for fea...
Best linear unbiased prediction (BLUP) has been used to estimate the fixed effects and random effect...
<p>wG-BLUP uses all SNPs (p = 400 K), but the contribution of each SNP to the genomic relationship m...
<p>Factor levels: 50 studies, sample size 5,000 individuals per study, 100k independent SNPs, and he...
<p>Top panel: Three models were developed for predicting the membership of a given SNP in the NHGRI ...
Predictive ability (PA) of GBLUP and RKHS statistical models obtained with 28,091 SNPs selected base...
<p>Dotted horizontal lines give the prediction R<sup>2</sup> obtained when all markers (p = 400,000)...
<p>(To increase readability, the log<sub>10</sub>(BFs) are truncated at 20). (A) Genome-wide log<sub...
In recent years, there has been a considerable amount of research on the use of regularization metho...
<p>Low-MAF: scenario where causal loci were over-sampled among loci with low minor allele frequency....
<p>PPH-1 – PolyPhen-1; PPH-2 – PolyPhen-2; PMD dataset – dataset from Protein Mutant Database; MMP –...
Background Genomic prediction requires estimation of variances of effects of single nucleotide polym...
<p>FHS = Framingham Heart Study, GEN = GENEVA, RAND: in this scenario causal and marker loci were dr...
Motivation: Using simulation studies for quantitative trait loci, we evaluate the prediction quality...
<p>Cross-validation revealed steady gains in prediction accuracy with respect to the NAM family-stra...
<p>Odds ratios (black squares) from the complete multivariate model (“chromstate+eqtl [M3]”) for fea...
Best linear unbiased prediction (BLUP) has been used to estimate the fixed effects and random effect...
<p>wG-BLUP uses all SNPs (p = 400 K), but the contribution of each SNP to the genomic relationship m...
<p>Factor levels: 50 studies, sample size 5,000 individuals per study, 100k independent SNPs, and he...
<p>Top panel: Three models were developed for predicting the membership of a given SNP in the NHGRI ...
Predictive ability (PA) of GBLUP and RKHS statistical models obtained with 28,091 SNPs selected base...
<p>Dotted horizontal lines give the prediction R<sup>2</sup> obtained when all markers (p = 400,000)...
<p>(To increase readability, the log<sub>10</sub>(BFs) are truncated at 20). (A) Genome-wide log<sub...
In recent years, there has been a considerable amount of research on the use of regularization metho...
<p>Low-MAF: scenario where causal loci were over-sampled among loci with low minor allele frequency....
<p>PPH-1 – PolyPhen-1; PPH-2 – PolyPhen-2; PMD dataset – dataset from Protein Mutant Database; MMP –...
Background Genomic prediction requires estimation of variances of effects of single nucleotide polym...
<p>FHS = Framingham Heart Study, GEN = GENEVA, RAND: in this scenario causal and marker loci were dr...