Theoretical predictions of power per causal SNP (upper panel) and out-of-sample <i>R</i><sup>2</sup> of the PGS (lower panel), for a trait that across studies has SNP heritability (<i>x</i>-axis) and cross-study genetic correlation (<i>y</i>-axis).
- Ronald de Vlaming (3663493)
- Aysu Okbay (3663496)
- Cornelius A. Rietveld (399384)
- Magnus Johannesson (123135)
- Patrik K. E. Magnusson (123143)
- André G. Uitterlinden (2213413)
- Frank J. A. van Rooij (215262)
- Albert Hofman (107303)
- Patrick J. F. Groenen (399394)
- A. Roy Thurik (399395)
- Philipp D. Koellinger (399385)
Publication date
January 2017
DOIAbstract
<p>Factor levels: 50 studies, sample size 5,000 individuals per study, 100k independent SNPs, and heritability arising from a subset of 1k independent SNPs.</p
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