Effect of treatment with TSA on Aβ42 and Aβ40 levels in APPswe/PS1dE9 transgenic mice.

<p>The Aβ42 and Aβ40 levels in the hippocampus of the WT control mice, vehicle-treated APPswe/PS1dE9 transgenic mice, and the APPswe/PS1dE9 transgenic mice treated with 30 mg/kg or 60mg/kg TSA were measured by ELISA. (A) Aβ40 was significantly decreased in two TSA-treated groups. (B) Aβ42 was notably decreased after treatment with 30 mg/kg and 60 mg/kg TSA. (C) After treatment with TSA, the ratio of Aβ42 to Aβ40 was not significantly altered. Data are presented as the mean±SEM, <i>n</i> = 20.*<i>p</i><0.05, **<i>p</i><0.01 versus WT control group; #<i>p</i><0.05, ##<i>p</i><0.01 versus vehicle-treated APPswe/PS1dE9 transgenic group.