A dose of 30 mg/kg TSA by intraperitoneal injection rescued the non-spatial cognitive impairment of APPswe/PS1dE9 transgenic mice aged 7 months.

<p>APPswe/PS1dE9 transgenic mice aged 7 months distinguished the novel object worse than the WT control mice, which indicated a poorer performance in the NOR. The deficits were alleviated by the treatment with 30 mg/kg TSA for 3 months from 3.5 months old. The preference index of the cognitive performance in the NOR of the four groups was expressed as the proportion of time spent exploring the novel object (time spent exploring the novel object/total time of exploration during the testing phase). (A) Preference index after 1-hour retention interval. (B) Preference index after 24-hour retention interval. WT, wild type; TG, transgenic; TSA, total salvianolic acid; <i>n</i> = 20, error bars represent SEM. *<i>p</i><0.05, **<i>p</i><0.01 versus WT control group; #<i>p</i><0.05, ##<i>p</i><0.01 versus vehicle-treated APPswe/PS1dE9 transgenic group.