Increase in generation and deposition Aβ in the brains of <i>APP^swe;PS1</i> mice.

<p>(A) ELISA analysis of Aβ40 peptides in the protein extracts of brains of <i>PS1</i> and non-transgenic control mice. The data were average +/− SEM from 5 mice for each genotype. (B) Sagittal brain sections (10 µm) of hippocampus area of 22-months old <i>APP^swe;PS1</i> and <i>APP^swe</i> female mice. The Aβ plaques were visualized by immunostaining with antibodies specific to ubiquitin and Aβ peptides (6E10). (C) Quantitative analysis of the levels of Aβ aggregation in the brains of <i>APP^swe;PS1</i> and <i>APP^swe</i> mice at 22 months of age by filter trap assay. (D) Quantification of the signals of Aβ aggregations in the filter trap assay using Image J program. (E) Analysis of Aβ deposition using unbiased stereology in the hippocampus of 22-months old <i>APP^swe;PS1</i> (n = 6) and <i>APP^swe</i> (n = 10) female mice.