Low GC content is correlated to susceptibility to some NNC motifs.

<p>A) Boxplots show the distribution of GC content of APOBEC-resistant (left) and APOBEC-vulnerable (right) gene sets. B) Plot showing the correlation coefficient (Y-axis) between our gene sets’ susceptibility to a particular motif on the bottom axis to its GC content. C) The correlation of a gene set’s mean susceptibility to the hotspot TT<u>C</u>, a GC-rich hotspot, to its GC content (red = resistant, green = vulnerable based on our clustering observations). D) Correlation of a gene set’s GC content to mean susceptibility for the hotspot CC<u>C</u>. E) Correlation between GC content of all gene sets and a measure of susceptibility based on the absolute number of nonsynonymous mutations at motifs. Susceptibility in this case is negatively correlated with motifs beginning with A and T, and more positively correlated with motifs beginning with G and C.