Correlation between gene copy number and corresponding gene expression values over all chromosomes.

<p>(A) The modified Manhattan plot gives the median (red line) of the externally centered correlation coefficient (ECCC) and the 5% and 95% quantile (black lines) along all chromosomal positions. The black dots indicate the probe sets with highest ECCC (ECCC>0.7, FDR adj. p<0.05). The triangles show the position of hotspot regions. High correlation between copy number variation and gene expression is not randomly distributed over the genome but mostly occurs within specific chromosomal regions (hotspots). (B) Example of the hotspot region on chromosome 1p35-1p34 comprising 185 genes (gray bars) with 17 highly correlating genes (red bars). Each dot represents the ECCC of a probe set based on the analysis of all 190 NSCLC cases.