Regional association plots at the two loci that exhibit genome-wide significance at discovery stage and one locus that showed suggestive evidence of association at <i>P</i>-value &lt;10⁻⁶.

<p>A) Chromosome 5 near <i>TMEM161B</i> and <i>MEF2C</i>, B) Chromosome 17 on <i>SFRS2</i> and C) Chromosome 13 on <i>FLT</i>. In each regional plot, the index SNP is represented by a purple circle for the meta-analysis of the five discovery studies and a purple diamond for meta-analysis of discovery and replication studies. The remaining SNPs are colour coded according to pairwise linkage disequilibrium (LD) with the index SNP on a scale of r² from 0 (blue) to 1 (red). Estimated recombination rates reflect the local LD structure in the 500 kb buffer around the index SNP and plotted based on values on Hapmap II CEU. Data for gene annotations are obtained from the RefSeq track of the UCSC Gene Browser (See LocusZoom <a href="http://csg.sph.umich.edu/locuszoom/" target="_blank">http://csg.sph.umich.edu/locuszoom/</a> more details).